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Sixteen compounds were carefully chosen and purchased from the Maybridge database for further experimental evaluation

A mild effect of the intervention was seen on fatigue while a moderate effect was observed on fatigability

Vilaplana-Prez, C., Aun, D., Garca-Flores, L.A., & Gil-Izquierdo, A

Although high selectivity of PAG for CSE over CBS has been reported (i.e., an IC 50 of 40 M for the CSE-catalyzed reaction using 1 mM of cysteine as the substrate, with no detectable inhibition of CBS even at 10 mM PAG), it also inhibits several other PLP enzymes, such as aspartate aminotransferase, alanine aminotransferase, and methionine -lyase (Sun et al., 2009)