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In this study, we confirmed the improvement of mitochondrial morphology as well as mitochondrial motility with PQQ pretreatment in the oxidative stress-induced premature senescence of auditory cells, which supports the protective aspect of PQQ in the mitochondrial quality control system

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The dual nature of astrocytic metabolism to balance neuroprotective lactate shuttling with pro-inflammatory lipid signaling underscores the importance of temporally precise therapeutic interventions