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The exact cause is unclear, but according to the National Eye Institute, the eyelid muscles and an area of the brain called the basal ganglia are involved

"When you use hydroquinone at a high percentage, it can cause darkening of the skin, instead of the desired fading of a particular spot," he says

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()-Phenserine Phenserine is an anti-acetylcholinesterase agent with additional non-cholinergic properties that was originally developed to treat AD (Poole and Agrawal, 2008
