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Hydrogen peroxide, unlike other free radicals, is able to be transported across cellular membranes

9 GSH peroxidases and related enzymes use GSH to detoxify peroxides

In particular, abundant evidence indicates metformin has significant anti-cancer activity

We propose a predisposition to tissue fragility in patients with clEDS, in particular of the gastrointestinal tract and emphasize the importance of counseling with regard to the risk of gastrointestinal complications