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In vitro and animal studies have found that lipoic acid exhibits immunomodulatory properties through mechanisms that stimulate the production of cyclic AMP (cAMP) (90, 91) a central regulator of innate immune functions and inhibits the migration of immune cells into the brain and spinal cord (92), possibly by decreasing endothelial expression of cell adhesion molecules, inhibiting expression of enzymes like matrix metalloproteinases (MMP), and/or reducing the permeability of the blood-brain barrier (87, 89, 93, 94)

Circular dichroism spectroscopy To analyse the secondary structure content and thermal stability of ROXY9 and GRXC2, far-UV spectra and thermal unfolding data were collected using circular dichroism spectroscopy (Chirascan, Applied Photophysics)

[DOI] [PMC free article] [PubMed] [Google Scholar] 277.Jackson CB, Farzan M, Chen B, Choe H

Global strategies for the prevention of neural tube defects through the improvement of folate status in women of reproductive age