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TABLE 2 Compound ( 10 ' 12 M) HGF Mimetic Activity N- heptanoyl-Tyr-Ile-(6) aminohexamide N- hexanoyl-Tyr-Ile-(6) aminohexamide ++++ N- pentaanoyl-Tyr-Ile-(6) aminohexamide _j N- butanoyl-Tyr-Ile-(6) aminohexamide +++ N- propananoyl-Tyr-Ile-(6) aminohexamide ++ N- acetanoyl-Tyr-Ile-(6) aminohexamide + N- benzoyl-Tyr-Ue-(6) aminohexamide + N- hexanoyl- (CH 2 -NIT 2 )-Tyr-Ile-(6) aminohexamide +++ Cell culture

GSH Deficiency and OxS in Aging GSH synthesis occurs in two steps, catalyzed by the enzymes glutamate cysteine ligase (GCL, comprised of catalytic and modifier subunits GCLC and GCLM), and GSS, to form the tripeptide glutathione (-glutamyl-cysteinyl-glycine) (22,23)