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L-carnitine reacts in the metabolism with fatty acids, so that so-called active fatty acids are formed

In contrast, no cells labeled with Fluro-Jade B were present in the brain of rat pups pretreated with L-carnitine [19]

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In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]