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Thus, peripheral infection accompanied by the release of endotoxins and/or DNA/RNA may stimulate inflammation mediated neural dysfunction within specific parts of the CNS as these cross the bloodbrain barrier

One key reason could be the decline in your bodys natural production of CoQ10 , a coenzyme essential for energy production
Effects of Androgens on Insulin Action in Women: Is Androgen Excess a Component of Female Metabolic Syndrome? Diabetes/Metabolism Research and Reviews, vol

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