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However, under pathological stressors such as chronic inflammation or oxidative stress, -synuclein undergoes conformational rearrangement: -helices destabilize, enabling transition into -sheet-rich oligomers 47,48

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Additionally, some catalases incorporate a tightly bound NADPH cofactor at the subunit periphery, enhancing the enzymes stability and regulatory capacity

In the 12 months before and 12 months after the final logged menstrual period, many participants spent more time awake during the night