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A lengthened synthetic version of insulin-like growth factor 1, carrying an extra amino-acid extension and a single substitution, IGF-1 LR3 is studied as a long-acting growth factor analogue

Lieber, C.S., Ethanol metabolism, cirrhosis and alcoholism
According to a review of the literature, if the pH of the solution is slightly higher than neutral pH (e.g., 7.19), but close to the point of zero charge (PZC), the surface will have a weak negative charge and little electrostatic interaction with nearby charged species 57