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However, long-term human studies specifically examining extended use remain limited
This damage can cause the nerve signal transmission between the spinal cord and different parts of the body to be disrupted, and consequently, neurological problems such as peripheral neuropathy occur

2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society
