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Sudiwala S, Palmer A, Massa V, Burns AJ, Dunlevy LPE, de Castro SCP, Savery D, Leung KY, Copp AJ, Greene NDE

106 Another in vitro study revealed that puerarin improves hypoxia-induced pulmonary vascular contraction and oxidative stress by activating the BMPR2/Smad and PPAR/PI3K/Akt signaling pathways, which reduces ROS and ET-1 levels in hypoxia-induced HPAECs

The following sections detail these core mechanisms within the conceptual framework of the two-hit model, wherein a perioperative insult is superimposed upon a pre-existing susceptible neural substrate (Figure 1)

Route: Ascent to Campa Pass (16,730 ft) and trek past numerous lakes