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Betaine cannot be converted back to choline but can spare some choline requirements for homocysteine remethylation (1)
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Mutations at residue 2209 which we showed to have a replication enhancing effect presented a similar accumulation in post LTX patients (Fig

This means the hyperplasia of melanocytes is restricted to the cell layer directly above the basement membrane of the epidermis where melanocytes normally reside
