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(PubMed) Stillwell W, Wassall SR
The low energy barrier for the rotation of the catechol group in DA allows greater conformational sampling and enables it to interact in close proximity to the subsite B of the primary binding site
doi:10.1016/j.biopsych.2008.04.022, PMID: 18534556 Magalhes PV, Dean OM, Bush AI, Copolov DL, Malhi GS, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M (2011) N -acetylcysteine for major depressive episodes in bipolar disorder
When alcohol is not present simultaneously to compete for the cytochromes, increased cytochrome activity results in an increased elimination rate for medications that these enzymes metabolize
