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( This coverage enables rational linker selection based on payload properties and desired release behavior, supporting ADC programs from early discovery through lead development

The detection results of MDA content showed that compared with the control group, after FAC treatment, MDA content was significantly increased, and after DFO treatment, the FAC-induced elevation of MDA showed a decreasing trend, but there was no statistically significant difference (Fig

This transformation involves increased or de novo expression of adhesion molecules, including E-selectin, P-selectin, intracellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) (Knottnerus et al., 2009)

Possible reasons could be that (1) DAB is preferred by LaccID over other aromatic substrates, and (2) DAB labeling was performed in sodium cacodylate buffer, which does not contain laccase inhibitors such as halides and thiols