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The compensatory mechanism of kyphotic deformity in old spinal fractures is complex, and although we found a relationship between TK, TLK, LACK, LL, and SVA and disc degeneration, none of the parameters was associated with disc degeneration at all levels

doi: 10.1038/sj.embor.7400559

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While neither tirzepatide nor niacinamide requires routine dose adjustment for hepatic impairment, patients with severe liver disease should be monitored closely if treatment is deemed necessary by the prescribing provider