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Chronic NSAID use for gout causes harm, e.g

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They can be tailor made to target certain tissue and achieve controlled drug release by altering the polymer features and surface chemistry (Panyam and Labhasetwar, 2003)

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Nature Reviews Endocrinology, 19(6), 345-360.

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And how can biology thread the needle between reaching for cellular immortality, and the potential malignant consequences

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