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Chronic NSAID use for gout causes harm, e.g

They can be tailor made to target certain tissue and achieve controlled drug release by altering the polymer features and surface chemistry (Panyam and Labhasetwar, 2003)
Nature Reviews Endocrinology, 19(6), 345-360.
And how can biology thread the needle between reaching for cellular immortality, and the potential malignant consequences
