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They can increase energy and improve quality of life for those with a deficiency, though individuals with normal B12 levels will not experience additional benefits from injections.

Biomolecules 15:885

If significant deficiency is confirmed via blood test, a loading dose protocol may be recommended in line with NICE guidance typically more frequent injections over the initial weeks to rapidly restore levels

Hence, the idea of engineering designer -Arrs that can selectively bind to receptors of choice and promote/inhibit downstream pathways has become an attractive area of research
