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doi: 10.1016/j.nutres.2013.02.002

With over 300 million cases globally, the prevalence of OA is reflected by a staggering $460 billion annual treatment expenditure, which imposes a substantial economic burden on both families and society [3]
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Not because the risk is high in a healthy adult without a cancer history, but because the consequence of missing a contraindication is high enough that the screening is worth doing without exception