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Acta Biomater 183:89100 [DOI] [PMC free article] [PubMed] [Google Scholar] 181.Valerio LSA, Carrick FR, Bedoya L, Sreerama S, Sugaya K (2023) Neural differentiation of induced pluripotent stem cells for a xenogeneic material-free 3D neurological disease model neurulation from pluripotent cells using a human hydrogel

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Impaired kidney function is also associated with increased IGFBP levels (e.g., IGFBP-1, -2, -3, -4, and -6) (75, 77) and IGFBP-3 protease activity, which subsequently increases low-molecular-weight IGFBP-3 fragments (78), most likely due to a compromised renal IGFBP-clearance ( Figure 4 )

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