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It is eliminated rapidly by the kidney and only metabolized to the extent of 10-15%, which suggests that effects are due to the parent compound

Lower concentrations (e.g., 1mg/mL using 5mL water) improve measurement accuracy but require larger injection volumes and may reduce stability due to increased surface area exposure to oxygen

Normally, glutathione helps neutralize NAPQI, but when acetaminophen is taken too frequently or in high doses, glutathione stores can become depleted
