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This approach has the potential to warn researchers to identify potential hazards before drugs are tested in animals or humans (Ramirez et al., 2013)

Researchers first identify promising biological observations in laboratory settings

The Underlying Toxic Mechanism of Gliotoxin Gliotoxin can induce cytotoxicities via different mechanisms, including the inhibition of angiogenesis, immunosuppressive activity, the inducement of cell apoptosis, the suppression of the activity of protease, the production of ROS and the inhibition of the enzymatic activity of peroxidases, the imbalance of oxireductase reaction, the induction of DNA damage, and the repression of specific genes expression, including NF-B factor [6]

For instance, patients with inflammatory bowel disease, such as Crohns disease, or those with celiac disease , may have trouble absorbing vitamin B12 due to gut damage