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Further experiments revealed that hydrogen-induced Nrf2 can directly bind to NF-B p65, interfering with its DNA-binding ability to pro-inflammatory gene promoters while also suppressing the release of inflammatory mediators such as HMGB1 and TNF-, thereby truncating the positive feedback loop of IKK

Potassium, Magnesium, and Calcium: Their Role in Both the Cause and Treatment of Hypertension [online]/ Available at: (Accessed on 24th December 2025)

10.1038/s41580-022-00547-x

They reported that the oxidation of the selenium center in 2,2-selenobis(benzamide) by H 2 O 2 does not produce the expected spirodiaza derivative 8, but it results in the formation of azaselenonium hydroxide [54]