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We herein report the case of a 15-year-old patient with MTHFR deficiency presenting with a slowly progressive mental decline and spastic paraplegia, followed by rapidly progressive psychosis and repetitive seizures triggered by infection that successfully responded to betaine treatment

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This adaptability is crucial in the context of skin fibrosis, where the modulation of gene expression in response to radiation can significantly influence the progression and severity of the condition

For example, such a relationship has been proposed in alcoholic liver disease [127] , iron-based hemochromatosis [128,129] , and Wilson disease [68]