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SMB-3 has been used to deliver the BDNF mimetic LM22A-4 selectively to ischemic brain regions, significantly improving neurological, motor, and cognitive function following ischemic stroke, reducing apoptosis and glial cell activation, increasing TrkB and Akt phosphorylation, and promoting neurogenesis

10.1016/j.brainresbull.2010.07.008 Summary Keywords neuroprotection, calpain, GSK-3, Bcl-2, and autophagy Citation Lazzara CA and Kim Y-H (2015) Potential application of lithium in Parkinson's and other neurodegenerative diseases

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