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Description
There is zero evidence for high B12 causing kidney problems
The most likely cause of the fatigue is l ack of production of creatine due to functional vitamin B12 deficiency (see below)
Current data suggests that this affects around 1 in 10 people aged 75 or over, and 1 in 20 people aged 65 to 74 in the UK
This framework helps distinguish whether an individual has actual nutrient insufficiency, mitochondrial stress, or metabolic dysfunction that might benefit from component-level support versus lifestyle intervention alone
