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The group of GPx enzymes, which play an irreplaceable role in the regulation of ROS homeostasis in vivo, has been thought to use GSH as a reducing agent to catalyze the reduction of H 2 O 2 or organic peroxides to generate water or corresponding alcohols, respectively [17]

In order to maintain the total cellular redox balance, ROS and antioxidants are strongly connected at the level of transcription and translation

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While many people describe it as a ringing in the ears, for some it may sound like high-pitched hissing, low-pitched roaring, chirping, screeching, buzzing, or humming