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Microtubular structure plays a key role in myelination, neuronal cytoskeletal junction, and cell-matrix attachment and has a dramatic effect on brain stiffness ( Molecular hydrogen is a new type of antioxidant with potent free radical scavenging ability, and its exertion of biological effects may also result from its extensive influence on metabolic pathways ( GSH plays a vital role in the neuronal antioxidant defense system and in maintenance of neuronal redox homeostasis

98 Additionally, tumor heterogeneity may contribute to ICI resistance as studies have demonstrated clonal neoantigen burden drives ICI responses and that T cell responses to sub-clonal neoantigens are blunted and may shape resistance

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in mild cognitive impairment and early Alzheimer s disease