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Long-term use of PPIs might raise your risk of B12 deficiency
There are only few case reports where vitamin B12 deficiency was solely attributed as the cause of pyrexia.[2,3,4] The exact cause of pyrexia in megaloblastic anemia is not known but a proposed mechanism is that megaloblastic anemia leads to hyperplasia and thus increased activity within the bone marrow leading to systemic pyrexia

GHK-Cu Safety Profile: Evidence Summary by Outcome Below is a framework summarizing the evidence level and frequency of side effects reported across available GHK-Cu studies

For this reason, under-eyes are believed to be more pronounced among individuals with vitamin B12 deficiency between their skin is pale