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Description
Morphological and functional metabolism studies link chronic pain and depressive disorders to dysfunctional neuroplastic changes in fronto-limbic brain regions that control emotional responses to painful injuries and stressful events
doi: 10.1111/j.1471-4159.2009.05896.x
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However, intranasal and oral administration as well as the discovery of antidepressant activity and lower psychotomimetic effect of isomers and metabolites of KET may foster a wider and longer-term clinical use of KET in the future (Zanos et al., 2016)
