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In this article, we review pivotal and recent studies on effects of exogenous melatonin on sleep and circadian rhythms in psychiatric disorders

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Meanwhile, Parkin is involved in the regulation of mitochondrial biogenesis via PARIS, a transcription factor that negatively regulates PGC1a and its target NRF1 or directly enhances TFAM-mediated mitochondrial transcription in proliferating cells (Kuroda et al., 2006