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Management and Treatment Strategies of MELAS The management of MELAS primarily revolves around symptomatic and supportive care, emphasizing a multidisciplinary approach to address the various organ systems involved

The Age-Related Eye Disease Studies (AREDS and AREDS2) remain the most influential trials in this context, demonstrating that specific combinations of antioxidants and minerals can reduce the likelihood of progression to advanced AMD in selected patient populations ( Although some studies suggest additive or synergistic effects when nutraceuticals are used alongside pharmacologic agents (Lafuente et al., 2019), definitive conclusions remain elusive due to the limited number of well-controlled trials designed to test such combinations

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A graphic figure summarizes the roles of some of these proteins in liver inflammation and lipid metabolism during NAFLD development and progression (Figure 2)