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The symptoms of vitamin B12 deficiency can be quite debilitating and include, according to scientific research: Chronic fatigue and weakness Shortness of breath Heart palpitations Tingling or numbness in the extremities Poor balance Loss of concentration and poor memory Disorientation Mood changes, including depression Insomnia Imagine trying to maintain a healthy, active lifestyle when you're constantly battling severe fatigue and low energy

doi: 10.1038/s41598-017-07004-2 13 LiuYChenHZhangLZhangTRenX

Schomburg L (2020) The other view: the trace element selenium as a micronutrient in thyroid disease, diabetes, and beyond

Closing perspectives: Balancing antioxidant activities and redox signaling We now know that in hepatocytes and perhaps in many metazoan cell types, cytosolic disulfide reducing power can come from NADPH via TrxR1, from NADPH via Gsr, or from Met catabolism [107]