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Three to five percent of these three caffeine metabolites remain as caffeine when eliminated through urine after undergoing additional demethylation and oxidation in the liver

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Physiol Plant 110:4251 Miura K, Okamoto H, Okuma E, Shiba H, Kamada H, Hasegawa PM, Murata Y (2013) SIZ1 deficiency causes reduced stomatal aperture and enhanced drought tolerance via controlling salicylic acid-induced ROS accumulation in Arabidopsis