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4 Long-term effects Research into nootropics is still limited which means there is a lot of uncertainty about the side effects the drugs may cause if used on an ongoing basis

Thus crown ethers solvate cations inside a hydrophilic cavity, whereas the outer shell, consisting of CH bonds, is hydrophobic

Articles were also excluded from the analysis when their methods and definitions had been superseded by new scientific evidence

*Correspondence: Kaiming Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers