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Moreover, USP7-mediated decrease of GATA1 poly-ubiquitylation was blocked by the USP7 inhibitors P5091 and P22077 (Figure 5C and Online Supplementary Figure S6B ), demonstrating that the enzymatic activity of USP7 is essential for the USP7-mediated deubiquitylation of GATA1

To detect whether the prolonged blood circulation time might increase their distribution in other organs, Cy7.5-labeled aPD-L1 was used to prepare fluorescent A2-APM, then saline and A2-APM (aPD-L1 equivalent dose 1.5 mg/kg) were intravenously given to GBM mice

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These nutrients are easily absorbed in the liposomal form