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MGO was thought to be formed non-enzymatically

ROS induce oxidative dimerization of the HIF prolyl hydroxylase, leading to its inactivation and HIF stabilization [52]

Importantly, higher levels of endogenous antioxidants are not a universal property of antioxidant application, and there are clear indicators that high levels of antioxidants cause stress, rather than relieve it

Through integrated proteomic and metabolomic analyses, we identified a high-inflammation, high-oxidation, low-metabolism triad in the hippocampus of CLP-induced SAE mice, providing novel insights into mechanisms underlying persistent cognitive deficits in SAE survivors