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mGlu2 receptors are found in many stations of the pain neuraxis and negatively modulate pain transmission in the first pain synapse between primary afferent fibers and second-order neurons in the dorsal horns of the spinal cord [164]

Informed consent was obtained from all participants in the study and the study was approved by the Scientific Ethical Committee of Rennes Hospital in France (Avis n 22.185)

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Atkin-Smith GK, Duan M, Chen W, Poon IKH