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In endometriosis, C-fibers are activated by inflammation and other noxious events which stimulate the release of substance P (SP), calcitonin gene-related peptide (CGRP), nitric oxide (NO), and tachykinins into the surrounding microenvironment [103]

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While this study does not provide recommendations for specific therapies, in the absence of approved treatments, insights from patient-reported experiences provide urgently needed real-world evidence for developing targeted patient care therapies and future clinical trials

PMID: 27517151 Citations are provided for research reference