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By 104 weeks, approximately 77% of SELECT patients on dose were receiving the target semaglutide 2.4 mg weekly dose, which is lower than the corresponding proportion of patients in STEP 1 (89.6% were receiving the target dose at week 68) 14,21

GSTs are a promising target because expression is enhanced in many tumors and high levels are sometimes correlated with poor prognosis

For UK researchers and institutions, establishing rigorous protocols begins with sourcing HPLC-verified peptides with transparent purity documentation, designing studies informed by published dose ranges, and maintaining ethical oversight appropriate for the experimental context