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48 In addition, vitamin B 12 is recognized to modulate the ecology of the gut microbiota

Since mitochondrial metabolism is prevalent in normal high-energy-demand tissues, such as the heart and liver, OXPHOS inhibitors (e.g., IACS-010759) have shown dose-limiting toxicities (DLT) in some clinical trials, hindering their widespread application [173]
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Collectively, these findings underscore the significance of NMDA receptors and offer clinical insights into potential treatments for chronic pain caused by central sensitization
