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Dicoumarol affects a structure change in NQO1 resulting in inhibitory effect on NQO1 activity

As a potential cancer treatment, it has also been observed that the effects of VIC on cancer are dependent on the route of administration, whether oral or intravenous, as well as on the mode of transport of VIC into tumoral cells (Figure 4)

The platform operates on the principle of generating uniform microdroplets that encapsulate m6Acontaining genes and the CRISPR/Cas13a detection system, wherein Cas13a recognizes the NCOA4 sequence and cleaves the reporter gene, resulting in amplified fluorescent signals within 20 min