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In conclusion, we demonstrated that BPC 157 application during reperfusion has a neuroprotective strategy that reduces ischemic neuronal damage and attenuates or even completely prevents ischemia/reperfusioninduced behavioral deficits in the water maze test and motor coordination failure in the inclined beam walk and lateral push test

Contraindications to sciatic nerve block may include include local infection and bed sores at the site of insertion, coagulopathy, preexisting central or peripheral nervous systems disorders, and allergy to local anesthesia

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However, in the present study, the expression of P53 IHC did not change in either the DOX or alamandine groups, indicating that DOX side effects are reduced independent of P53