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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

This multifactorial nature means that addressing only one aspect, like pigmentation, without understanding the internal imbalances may not provide lasting relief

Although CRE has differential expression of antioxidants post-irradiation, the effects were limited

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