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reported that AS-IV can enhance the If current density in I/R-injured sinoatrial node cells, shorten APD at 20% and 50% repolarization in SAN cells, and upregulate HCN4 expression, thus helping maintain cell volume and cytoskeletal integrity in SAN cells, with potential therapeutic effects for sick sinus syndrome (Liu et al., 2018)

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CIPN, chemotherapyinduced peripheral neuropathy

In males, early testosterone depletion has been identified as a risk factor for early-onset AD, with lower testosterone levels frequently linked to cognitive impairment [180]