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Other recognized motor signs and symptoms include gait and posture disturbances such as festination (rapid shuffling steps and a forward-flexed posture when walking), speech and swallowing disturbances including voice disorders, masklike face expression or small handwriting, although the range of possible motor problems that can appear is large

After interruption of gemcitabine and symptomatic treatment, the evolution of haemolytic anaemia was generally favourable, but this was not the case for renal dysfunction: two complete and one partial resolution of renal insufficiency were noted, but one case required chronic dialysis

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However, radiotherapy is a double-edged sword