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Despite the growing recognition of the clinical and economic benefits of optimizing medication use through pharmacogenomics, CYP2D6 genotyping still faces challenges in widespread implementation in clinical practice, particularly due to the complexity of identifying structural variants

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Moreover, certain microbial strains generate endogenous ethanol, further promoting LPS release and ROS accumulation in hepatic stellate cells (HSCs) [70, 71]

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This allows for targeted analgesia with minimal impact on other isoforms

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