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This is most likely not a physiological change due to aging per se , but a consequence of the elderly being more prone to gastric dysfunction, with variable degrees of gastric atrophy and achlorhydria interfering with the absorption of vitamin B 12 from foods (Carmel, 12 among the elderly are accompanied by metabolic changes related to deficiency (Carmel, 2015)

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The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes PubMed

Truncation of CGI-58 protein causes malformation of lamellar granules resulting in ichthyosis in Dorfman-Chanarin syndrome