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Its deficiency is seen in people with poor nutrition, infection, cancer, surgery, alcohol, pernicious anemia, medications (PPIs or other acid-suppressing drugs), exposure to nitrous oxide (during surgery or recreational use), stomach/intestinal problems such as intestinal dysbiosis, leaky gut or gut inflammation, atrophic gastritis or hypochlorhydria (low stomach acid) and/or nerve damage

Unlike sterile water for injection, which is intended for single-use only and must be discarded after the seal is broken, bacteriostatic water can be safely used multiple times over a period of up to 28 days after initial puncture

Clinical Trials: Impact of B12 Supplementation on Metabolites Serum B12 Holotranscobalamin Methylmalonic Acid Homocysteine Notes on Clinical Trials of B12 Supplementation Appendix C

in addition, the results obtained for mRNA and protein expression showed the same trend