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At the clinical strategy level, the establishment of quantifiable metabolic readouts, such as the Kyn/Trp ratio, the expression of key metabolic enzymes or transporters, and the proportions of signaling metabolites, combined with stratified interventions based on disease stage and tissue involvement, may help further promote tissue repair and restoration of immune homeostasis while suppressing inflammatory responses, thereby enabling treatment strategies for autoimmune diseases with greater long-term benefit (139)

Blockade of the GLT-1 transporter in the central nucleus of the amygdala induces both anxiety and depressive-like symptoms

Gupta, R

(2021) derived iPSCs from blood mononuclear cells of two KSS patients and found that cells could be differentiated into neural progenitors, fibroblast-like cells, and cardiomyocytes without signs of mitochondrial defects